The release of podocyte-derived microparticles into the urine may reflect early kidney injury in diabetes. Several hybrid closed-loop systems have been commercialised, reflecting rapid transition of this evolving technology from research into clinical practice, where it is gradually transforming the management of type 1 diabetes in children and adults. Identify all potential conflicts of interest that might be relevant to your comment. Catalyzes the formation of cAMP in response to calcium entry leadings to cAMP signaling activation that affect processes suche as synaptic plasticity and insulin secretion. prognostic factor and outcome prediction studies, serve different purposes, which should be reflected in how the results are summarized in reviews. A conditional knockout of mir-10b in KIT + cells or depletion of KIT + cells in mice leads to degeneration of β cells and ICCs, resulting in diabetes and gastroparesis. LetPub Scientific Journal Selector (2018-2021), FREE RADICAL BIOLOGY AND MEDICINE published in 1987, UNITED STATES. ... Diabetologia. Diabetologia. Since failed resolution of inflammation is a major contributor to the progression of diabetic nephropathy, identifying endogenously generated molecules that promote the physiological resolution of inflammation may be a promising therapeutic approach for this disease. Impact Factor 0.119. The full text of the Journal of Hepatology is available online via two sources: . This post hoc subgroup analysis aimed to evaluate the effectiveness of patiromer, a sodium-free nonabsorbed polymer, in lowering serum potassium levels in older patients receiving a renin-angiotensin-aldosterone system inhibitor with chronic kidney disease … We have detected that you are using an Ad Blocker. Recently, it was shown that, compared to the other isoforms, the expression of NOX5 was increased in the patients with DN and, NOX5 has been suggested to be important in the development of therapeutic agents. Values shown are normalized to protein levels in tissue homogenates. Valerio G, Licenziati MR, Iannuzzi A, Franzese A, Siani P, Riccardi G, et al. 14. Graphical abstracts should be submitted as a separate file in the online submission system. Citations of this article. Our findings support CCR9 as a new therapeutic target for type 2 diabetes via the gut–VAT–liver axis. May 6, 2020 PhD Voice Journal Leave a Comment on Diabetologia Croatica. Cerebral injury (cerebral edema) is an uncommon but potentially devastating consequence of diabetic ketoacidosis (DKA). The graphical representation of the percentage referable retinopathy against number of consecutive missed appointments (Fig. The impact of hospital-diagnosed depression or use of antidepressants on treatment initiation, adherence and HbA 1c /LDL target achievement in newly diagnosed type 2 diabetes. 2021; 64(3):571-580 (ISSN: 1432-0428) Devaraj SM; Kriska AM; Orchard TJ; Miller RG; Costacou T The current treatment options for patients with anemia of chronic kidney disease (CKD), as discussed by others in this issue of the supplement, include i.v. Maternal food consumption during late pregnancy and offspring risk of islet autoimmunity and type 1 diabetes Johnson, Randi K.; Tamura, Roy; Frank, Nicole; Uusitalo, Ulla; Yang, J Supplements may be accepted after editorial review. Abstract To capture the experience of parents of youth with recent onset Type 1 diabetes who initiated use of continuous glucose monitoring (CGM) technology soon after diagnosis, which is a new practice.Focus groups and individual interviews were conducted with parents of youth with Type 1 diabetes who had early initiation of CGM as part of a new clinical protocol. Our journal is ranked in the top quartile of Endocrinology & Metabolism category of the 2019 JCR Impact Factors. Here, we aimed to analyze the relationships between peripheral blood circulating immune cell subsets, plasmatic microRNAs, and T1D. We measured the urinary excretion of podocyte-derived microparticles in youth with type 1 and type 2 diabetes, and related the values to blood pressure, renal function and blood glucose levels. LetPub Scientific Journal Selector (2018-2021), DIABETOLOGIA published in 1965, GERMANY. The current treatment options for patients with anemia of chronic kidney disease (CKD), as discussed by others in this issue of the supplement, include i.v. The full text of the Journal of Hepatology is available online via two sources: . Catalyzes the formation of cAMP in response to calcium entry leadings to cAMP signaling activation that affect processes suche as synaptic plasticity and insulin secretion. Blood samples were obtained from both children with T1D at diagnosis and age-sex matched healthy controls. Supplementary Information. Colors show changes in H3K27Ac enrichment, and dot size … Insulin resistance and impaired glucose tolerance in obese children and adolescents from Southern Italy. Graphical abstract. Structures similar to CBs have been identified in the amphibian oocyte nucleus (called sphere organelles) and in … The main outcome measure was development of type 1 diabetes. Graphical abstract The graphical abstract is mandatory at submission of the revised version of the paper. It is the policy of Acta Diabetologica to ensure balance, independence, objectivity and scientific rigor in the journal. 26 Readers. LXR Phosphorylation-Deficient Mice Show Reduced Cholesterol Levels in Response to an HFHC Diet (A) Plasma total cholesterol levels in mice fed a chow (n = 4/group) or an HFHC diet (n R 5/group). Several diets have been proposed, with various effects specifically on liver steatosis. The aim of this study was to investigate, in a multicenter retrospective cross-sectional study, sex-gender difference in DR in a large sample of type 2 [...] Halftone art: • Definition: Photographs, drawings, or paintings with fine shading, etc. Graphical Abstract: Abstract: Background: Despite a number of innovations in anti-diabetic drugs and substantial improvement in diabetes care, the number of people with diabetes continues to increase, suggesting further need to explore novel approaches to prevent diabetes. The graphical abstract should be submitted for editorial review as a separate file, selecting the appropriate file-type designation in the journal’s online submission system. miR-10b-5p is highly expressed in ICCs from healthy mice, but drastically depleted in ICCs from diabetic mice. Quality Of Reviewer Comments (Click To Rate!) View PDF. VDAC1 inhibitors, including metformin, restore insulin secretion in T2D islet donors and prevent hyperglycemia in diabetic mice. The online version contains peer-reviewed but unedited supplementary material available at 10.1007/s00125-021-05437-z. It is also used to achieve ovulation in polycystic ovary syndrome (PCOS). modification to dietary patterns) having a limited impact in reducing the incidence of these metabolic diseases. At the electronic-microscope level, they are composed of heterogeneous mixture of electro-dense particles with diameters ranging from 20-25 nm and are called coiled body. Diabetologia. 12. DOI: 10.1007/s00125-020-05277-3. Sodium/glucose cotransporter 2 (SGLT2) inhibitors slow the progression of chronic kidney disease and prevent heart failure events. (B) Hepatic total cholesterol levels in mice fed a chow (n = 4/group) or HFHC diet (n = 6/group). Data files and R code for all analyses are available at https://github.com/rodriguesk/T1D_truculture_diabetologia . ABSTRACT ABSTRACT. Forecasting the changing burden of chronic diseases such as type 2 diabetes in Singapore is vital to plan the resources needed and motivate preventive efforts. This trial compared the effects of intermittent calorie restriction (the 5:2 diet) and a low-carb high-fat diet (LCHF) on reduction of hepatic steatosis. The first-line treatment for non-alcoholic fatty liver disease (NAFLD) is weight reduction. Graphical Abstract Competition; 0. However, SGLT2 inhibitors may increase the risk for acute kidney injury (AKI). Zhang et al. RESEARCH DESIGN AND METHODS Eighteen male type 2 diabetic and 20 healthy male … Pancreatic beta cells are usually thought as passive victims of immune cell attack in type 1 diabetes (T1D). DOI: 10.1007/s00125-021-05405-7 We examined whether exercise training could restore mitochondrial function and insulin sensitivity in patients with type 2 diabetes. Congenital malformations of the spinal cord include a wide range of abnormalities that vary considerably in imaging and clinical characteristics and complexity and therefore may represent a diagnostic challenge, even for the experienced ... Diabetologia 2012;55(4):936–947. As the official journal of European Association for the Study of Diabetes, we are committed to ensuring high visibility for your publication through the society membership, libraries and social media. Graphical abstract: [Figure not available: see fulltext.] • Vector graphics containing fonts must have the fonts embedded in the files. Molecular and Cellular Endocrinology was established in 1974 to meet the demand for integrated publication on all aspects related to the genetic and biochemical effects, synthesis and secretions of extracellular signals (hormones, neurotransmitters, etc.) Objective Singapore is a microcosm of Asia as a whole, and its rapidly ageing, increasingly sedentary population heralds the chronic health problems other Asian countries are starting to face and will likely face in the decades ahead. View This Abstract Online; Fasting blood glucose at admission is an independent predictor for 28-day mortality in patients with COVID-19 without previous diagnosis of diabetes: a multi-centre retrospective study. Methods Using data from the Swedish National Diabetes Registry, 14,372 adults with type 1 diabetes with a new registration of FM during 2016–2017 and with … VDAC1 upregulation leads to ATP depletion and impaired insulin secretion. Immune cell subsets and microRNAs have been independently proposed as type 1 diabetes (T1D) diagnostic and/or prognostic biomarkers. Our objective was to assess whether SGLT2 inhibitor use, compared with all other glucose-lowering drugs (oGLDs), is associated with increased rates of AKI. Mendeley users who have this article in their library. Objective: We summarized evidence from prospective studies that examined associations of dietary patterns with type 2 diabetes by considering different methodologic approaches. This hybrid open-access journal is an official title of Diabetes UK, which over that the last decade has invested £67+ million in diabetes research. According to the most recent guidelines by the American Heart Association, all patients with hypertension should adopt the following dietary advices: increased consumption of fresh fruits, vegetables, low-fat dairy products and sodium reduction. Graphical abstract Introduction Recent studies show that diagnosis of type 2 diabetes at younger ages is associated with greater excess CVD risk than when the diagnosis occurs later in life [ 1 , … It should summarize the contents of the article in a concise, pictorial form designed to capture the attention of a wide readership. The incidence of diabetes mellitus is approaching global epidemic proportions and should be considered a major health-care problem of modern societies in the twenty-first century. and to the understanding of cellular regulatory mechanisms involved in hormonal control.. Graphical abstract ... Diabetologia 36: 883±892. Cart. This post hoc subgroup analysis aimed to evaluate the effectiveness of patiromer, a sodium-free nonabsorbed polymer, in lowering serum potassium levels in older patients receiving a renin-angiotensin-aldosterone system inhibitor with chronic kidney disease … This highlights the benefits of exercise training and presents putative target pathways for preventing lipotoxicity in skeletal muscle, which is typically associated with the development of type 2 diabetes. Diabetic Medicine focuses on disseminating research on all aspects of diabetes to improve the management of people with the disease. Karvonen M, Pitkäniemi M, Pitkäniemi J, Kohtamäki K, For these migrants, as for virtually all population groups living in the western world, cardiovascular disease (CVD) is the main cause of death. Blood samples were obtained from both children with T1D at diagnosis and age-sex matched healthy controls. LXRa Phosphorylation at S196 Affects Global H3K27 Acetylation and LXR and TBLR1 Occupancy in the Ces1f Gene (A) Volcano plot comparing differences in gene expression and H3K27Ac enriched sites shows log2 ratio versus log10 p value of differentially expressed genes in S196A versus WT livers exposed to HFHC (n = 3). Statin therapy is associated with a slightly increased risk of development of diabetes, but the risk is low both in absolute terms and when compared with the reduction in coronary events. Types of papers. OBJECTIVE Mitochondrial dysfunction and fat accumulation in skeletal muscle (increased intramyocellular lipid [IMCL]) have been linked to development of type 2 diabetes. Diabetologia 2003; 46:579. Abstract. Annexin A1 (ANXA1), as an endogenous mediator, plays an important role in resolving inflammation. Background/Aims. Canagliflozin reduced kidney disease progression in participants with type 2 diabetes in the CANagliflozin cardioVascular Assessment Study (CANVAS) Program. Therefore we set out to investigate how authors of reviews synthesize and report the results of primary outcome prediction studies. Pre-natal exposure to metformin results from its continuation after a successful ovulation in women with PCOS, its maintenance in women with pre-gestational diabetes or the installation of metformin in GDM. The Journal of Hepatology publishes original papers, reviews, case reports and letters to the Editor concerned with clinical and basic research in the field of hepatology.The Journal is published in English. Graphical Abstract. 37 References; 685 Citing Articles; Letters Related Articles; Abstract Background. report on the role of the ATP-conducting mitochondrial outer membrane voltage-dependent anion channel-1 (VDAC1) in β cell glucotoxicity preceding diabetes. now demonstrate that a subpopulation of beta cells becomes senescent and actively promotes the immune-mediated destruction process. Structures similar to CBs have been identified in the amphibian oocyte nucleus (called sphere organelles) and in … A conditional knockout of mir-10b in KIT + cells or depletion of KIT + cells in mice leads to degeneration of β cells and ICCs, resulting in diabetes and gastroparesis. Study Protocols. Quality Of Reviewer Comments (Click To Rate!) Objectives: To assess whether vitamin D supplementation in infancy reduces the risk of type 1 diabetes in later life. Older people are more likely to have reduced kidney function and multiple comorbid conditions predisposing them to hyperkalemia. A systems view of type 2 diabetes-associated metabolic perturbations in saliva, blood and urine at different timescales of glycaemic control 0 Citations. Diabetologia Croatica. Clinical practice in patients with moderate or high cardiovascular … Epidemiology provides a scientific basis for clinical and public health practice. All authors are expected to disclose to the readers any real or apparent conflict of interest that may have a direct bearing on the subject matter of the article. Credit: Diabetologia (2021). Parts of this study were presented in abstract form at the 52nd Annual Meeting of the European Association for the Study of Diabetes, Munich, Germany, 12–16 September 2016, and at the 77th Scientific Sessions of the American Diabetes Association, San Diego, CA, 9–13 June 2017. This analysis explored potential mediators of the effects of canagliflozin on kidney outcomes. View This Abstract Online; Cardiovascular health in early adulthood predicts the development of coronary heart disease in individuals with type 1 diabetes: 25 year follow-up from the Pittsburgh Epidemiology of Diabetes Complications study. We review and quantitatively summarise the evidence from observational studies in a meta-analysis. Diabetic neuropathy is a common chronic complication of diabetes and, although an adequate glycemic control can reduce the frequency of diabetic neuropathy in type 1 diabetes, the majority of type 2 diabetic … miR-10b-5p is highly expressed in ICCs from healthy mice, but drastically depleted in ICCs from diabetic mice. Older people are more likely to have reduced kidney function and multiple comorbid conditions predisposing them to hyperkalemia. Since failed resolution of inflammation is a major contributor to the progression of diabetic nephropathy, identifying endogenously generated molecules that promote the physiological resolution of inflammation may be a promising therapeutic approach for this disease. ... Graphical abstract. AB - Aims/hypothesis: In this study we examined the cost-effectiveness of three different screening strategies for diabetic retinopathy: using a personalised adaptive model, annual screening (fixed intervals), and the current Dutch guideline (stratified based on previous retinopathy grade). 2020; 63(10):2102-2111 (ISSN: 1432-0428) Diabetologia; 64(1): 119-128, 2021 Jan. Artigo em Inglês | MEDLINE | ID: mdl-33026463. The percent mediating effect of 18 biomarkers indicative of disease was determined by comparing the hazard ratios for the effect of … • Halftones should have a minimum resolution of 300 dpi. Figure 3. Indeed, epidemiology can be used to guide how we define, diagnose, and screen for diabetes, to describe the present and future burden of diabetes, and to highlight opportunities for intervention. A systematic, data-driven approach to identify risk variables for the prediction of type 2 diabetes is necessary for the practice of precision medicine.Graphical abstract (Source: Diabetologia) Data-driven assessment, contextualisation and implementation of 134 variables in the risk for type 2 diabetes: an analysis of Lifelines, a prospective cohort study in the Netherlands Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review Clinical management of metabolic syndrome: report of the American Heart Association/National Heart, Lung, and Blood Institute/American Diabetes Association conference on scientific issues related to management. Many prognostic models have been developed. Graphical abstracts will appear in the html version of a paper (not the pdf) and will also be used in Diabetologia’s electronic tables of contents (eTOC) alerts, on our website and on twitter. The signalling peptide endotrophin is derived through proteolytic cleavage of the carboxyl-terminal during formation of type VI collagen. Graphical abstract Advances in diabetes technologies have enabled the development of automated closed-loop insulin delivery systems. Flow diagram of patient selection. Abstract Diabetic retinopathy (DR) is one of the main causes of visual loss in individuals aged 20–64 years old. Graphical abstract. May 6, 2020 PhD Voice Journal Leave a Comment on Diabetologia Croatica. Introduction Lifestyle modification is one of the cornerstones in the management of hypertension. Different types of models, i.e. Manuscripts must include a structured abstract (maximum 250 words), should not exceed 3,000 words of text and should be limited to 30 references (AMA style, see section 4). Graphical abstract Supplementary Information The online version contains peer-reviewed but unedited supplementary material available at 10.1007/s00125-021-05458-8. Background: Different methodologic approaches for constructing dietary patterns and differences in their composition limit conclusions on healthful patterns for diabetes prevention. Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › … For examples, please click here. People of non-European origin form around 7% of the total UK population. Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review Abstract. The liver-alpha cell axis associates with liver fat and insulin resistance: a validation study in women with non-steatotic liver fat levels.

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